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Abstract : |
Four groups of 24 male Wistar albino rats (Rattus norvegicus) were exposed to lead acetate trihydrate (0, 0.5, 1.0, and 2% for 1 to 6 months) in drinking water to investigate the ultrastructural alterations in the renal cortical tissues due to lead intoxication. In comparison with respective control rats, chronic exposure to subtoxic doses of lead had produced adverse alterations mainly in the mitochondria, endoplasmic reticulum, lysosomes and nuclear chromatin with basal membrane infoldings. These changes were mainly seen in the proximal convoluted tubules and increased severely with increasing dose and/or time interval of lead exposure. , Four groups of 24 male Wistar albino rats (Rattus norvegicus) were exposed to lead acetate trihydrate (0, 0.5, 1.0, and 2% for 1 to 6 months) in drinking water to investigate the ultrastructural alterations in the renal cortical tissues due to lead intoxication. In comparison with respective control rats, chronic exposure to subtoxic doses of lead had produced adverse alterations mainly in the mitochondria, endoplasmic reticulum, lysosomes and nuclear chromatin with basal membrane infoldings. These changes were mainly seen in the proximal convoluted tubules and increased severely with increasing dose and/or time interval of lead exposure., |
