t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
| Author(s) : | Karen Seiter Ahmed Tauseef Lai Yongrong Primanneni Suneeta Shimonov Josif Liu Delong, |
| Publisher : | N/A |
| Publication Date : | 2007 |
| ISSN : | N/A |
| Abstract : | Abstract Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma. , |