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Abstract : |
So far, there have been a lot of evidence about local renin-angiotensin system (RAS) in pancreas. The acting of the tissue RAS is probably independent of circulating counter part and its activity is specified by the needs of individual tissues. This review focuses on the current state of knowledge about of the physiology of RAS as well as its potential role in pancreatic diseases including acute and chronic pancreatitis, diabetes mellitus, cysticfibrosis and cancer. Recent immunohistochemical studies on rats have shown that both ATt and AT2 receptor subtypes as well as angiotensin II are localized predominantly in the epithelia of pancreatic ducts and endothelia of blood vessels. Their presence has also been observed in the acinar cells, pancreatic islets and pancreatic stellate cells. The regulation of RAS tissue is a subject to transform by means of a number of factors such as hormones, ions and stress. The ACE inhibitors and ATt receptor antagonists may be significant in treatment of chronic pancreatitis and diabetes mellitus. Candesartan and lisinopril significantly suppressed pancreatic myeloperoxidase activity, hydroxyproline content, ratio of fibrous tissue and ratio of activated pancreatic stellate cells., |
