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Abstract : |
Renal clearance of endogenous creatinine and acetylsalicylic acid was investigated in 12 healthy male volunteers. Blood and urine samples were collected at pre-determined time intervals. The concentration of acetylsalicylic acid (as salicylates) and creatinine in plasma and urine were determined colorimetrically. Mean +SE values were found to be, for diuresis 0.031+0.011 mLmin‾1 kg‾1, Plasma concentration of creatinine and salicylic acid 15.11+0.166 μg mL‾1 and 29.38+0.12 μg mL‾1, urine concentration of creatinine and salicylic acid 855.73+1.53 μg ml‾1 and 38.30+0.43 μg mL‾1, renal clearance of creatinine and salicylic acid 1.52+0.08 ml min‾1 kg‾1 and 0.063+0.02 mL min‾1 kg‾1 and clearance ratio 0.054+0.016. The results indicated that there is less renal clearance of acetylsalicylic acid in local environment when compared with values given in literature. , Renal clearance of endogenous creatinine and acetylsalicylic acid was investigated in 12 healthy male volunteers. Blood and urine samples were collected at pre-determined time intervals. The concentration of acetylsalicylic acid (as salicylates) and creatinine in plasma and urine were determined colorimetrically. Mean +SE values were found to be, for diuresis 0.031+0.011 mLminأƒآ¢أ‚€أ‚آ¾1 kgأƒآ¢أ‚€أ‚آ¾1, Plasma concentration of creatinine and salicylic acid 15.11+0.166 أƒإ½أ‚آ¼g mLأƒآ¢أ‚€أ‚آ¾1 and 29.38+0.12 أƒإ½أ‚آ¼g mLأƒآ¢أ‚€أ‚آ¾1, urine concentration of creatinine and salicylic acid 855.73+1.53 أƒإ½أ‚آ¼g mlأƒآ¢أ‚€أ‚آ¾1 and 38.30+0.43 أƒإ½أ‚آ¼g mLأƒآ¢أ‚€أ‚آ¾1, renal clearance of creatinine and salicylic acid 1.52+0.08 ml minأƒآ¢أ‚€أ‚آ¾1 kgأƒآ¢أ‚€أ‚آ¾1 and 0.063+0.02 mL minأƒآ¢أ‚€أ‚آ¾1 kgأƒآ¢أ‚€أ‚آ¾1 and clearance ratio 0.054+0.016. The results indicated that there is less renal clearance of acetylsalicylic acid in local environment when compared with values given in literature., |
