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Abstract : |
Introduction: It has been suggested that disturbances of circadian and seasonal rhythmicity in the release of melatonin (MLT) may be amongthe causes of recurrence of peptic ulcers. Similar seasonal regularity is observed in clinical pictures of functional dyspepsia (FD). However, there are no reports on possible role of MLT in pathogenesis of dyspepsia. Aim of study: The aim of the study was to investigate nocturnal secretion in subjects in different subgroups of FD. Material and methods: The investigations were carried out in 53 patients, aged 20-54 years. According to the results of clinical and enodoscopic examinations and Rome III Criteria - epigastric pain syndrome (EPS) was diagnosed in 28 patients and postprandial distress syndrome (PDS) in 25 patients. 25 healthy persons, aged 25-45 years, constituted the control group (K). Blood samples were taken from each subject at 10.00 p.m., 2.00 a.m. and 6.00 a.m. Melatonin concentration was measured with EUSA method (enzyme linked immunosorbentassay). Results: The average concentration of MLT in healthy subjects was 34.7s8.1 pg/ml, in patients with EPS - 40.4s9.1 pg/ml (p>0.05) and with PDS - 60.1s10.2 pg/ml (p<0.05). Conclusions: 1. Nocturnal secretion of MLT in patients with different subgroups of FD is varied. 2. Diversity of MLT secretion may be the cause of different dyspeptic symptoms, |
