Home

Identification of genetic networks from a small number of gene expression patterns under the Boolean network model


Author(s) : Satoru Kuhara Satoru Miyano Tatsuya Akutsu, 
Publisher : N/A
Publication Date : 1999
ISSN : N/A
Abstract : for inferring genetic network architectures from state transition tables which correspond to time series of gene expression patterns, using the Boolean network model. Their results of computational experiments suggested that a small number of state transition (INPUT/OUTPUT) pairs are sufficient in order to infer the original Boolean network correctly. This paper gives a mathematical proof for their observation. Precisely, this paper devises a much simpler algorithm for the same problem and proves that, if the indegree of each node (i.e., the number of input nodes to each node) is bounded by a constant, only O(log n) state transition pairs,