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Abstract : |
To consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extractsfrom four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba,Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats wereadministered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used asa diabetic control. Effect of extracts from four medicinal plants on blood glucose levels of diabetic ratswas determined at various time interval for 9 h after oral administration of the first extract at 100 mgdose /kg body weight. In addition, GOT, GPT, LDH, total cholesterol (TC) and triglyceride (TG) weredetermined 7 days after daily oral administration of each extract. The glucose levels of diabetic ratstreated with C. coronarium and M. alba were significantly decreased, respectively, at 3 h and 5 h afteradministration (p<0.05). The enzyme activities of GOT, GPT and LDH of diabetic rats were alsodecreased in diabetic rats treated with four plant extracts respectively. In particular, the administrationof extract from M. alba tends to bring the GOT, GPT and LDH values of diabetic rats to near normal.There was no significant difference in TC between diabetic control and diabetic rats treated,respectively, with extracts of C. coronarium, D. batatas and M. alba, except C.unshiu extract showinga significant decrease when compared to the diabetic control. The TC value was brought down by33.3% fall from the value of diabetic rats, which shows more decrease than that of glibenclamide-treatedones. There was a significant difference in TG between the diabetic control and diabetic ratstreated, respectively, with extracts of C. coronarium, D. batatas, M. alba and C.unshiu. The resultssuggest that the administration of C. coronarium and M. alba have a hypoglycemic effect in diabeticrats and their effect was equivalent to that of glibenclamide. The administration of C.unshiu showsmore antihyperlipidemic effect than antidiabetic effect., |
