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Abstract : |
The major aim of this investigation was to examine the effect of aqueous extract of Prasium majus`s L. leaves (AEPML) on intestinal influx of water and electrolytes by Everted Gut Sac (EGS). Four segments of rat intestine were detected and used (duodenum, jejunum, ileum and colon). The extract of the plant was used with two concentrations,8 and أƒâ€ڑأ‚آ 16 g L-1, respectively. The results obtained showed that AEPML provoke; firstly أƒâ€ڑأ‚آ an أƒâ€ڑأ‚آ inhibition أƒâ€ڑأ‚آ of أƒâ€ڑأ‚آ water أƒâ€ڑأ‚آ secretion by أƒâ€ڑأ‚آ أƒâ€ڑأ‚آ different أƒâ€ڑأ‚آ parts أƒâ€ڑأ‚آ of أƒâ€ڑأ‚آ EGS, but decrease was only significant at the ileum (p<0.05).Secondly electrolytes fluxesأƒâ€ڑأ‚آ wereأƒâ€ڑأ‚آ alsoأƒâ€ڑأ‚آ sensitive toأƒâ€ڑأ‚آ the additionأƒâ€ڑأ‚آ of AEPML.On أƒâ€ڑأ‚آ the أƒâ€ڑأ‚آ other hand أƒâ€ڑأ‚آ for أƒâ€ڑأ‚آ Na+ influx,weأƒâ€ڑأ‚آ notedأƒâ€ڑأ‚آ anأƒâ€ڑأ‚آ inhibitionأƒâ€ڑأ‚آ of the secretion at the duodenum and the colon (p < 0.01) with the dose 8 g L-1, while for Cl-, influx this inhibition was only registered at the colon (p<0.01) with the dose 8 g L-1. For K+ influx, AEPML induced rather a significant reabsorption at the duodenum, the jejunum and theأƒâ€ڑأ‚آ colon أƒâ€ڑأ‚آ (p < 0.01) hileأƒâ€ڑأ‚آ atأƒâ€ڑأ‚آ the ileumأƒâ€ڑأ‚آ the reabsorption increased. Thisأƒâ€ڑأ‚آ wasأƒâ€ڑأ‚آ onlyأƒâ€ڑأ‚آ significantأƒâ€ڑأ‚آ with the dose 16أƒâ€ڑأ‚آ g L-1.It may be concluding that the heterogeneity of the gastrointestinal tract in response to numerous factors which are able to affect homeostasis of water and electrolytes. AEPML might have an antisecretory function on water Na+ and Cl- and an absorptive function on K+., |
