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Abstract : |
The aim of the current study was to determine the efficacy of selected canola or mustard seeds (S) and canola sprouts (SP) cultivars (5 and 10% levels) on azoxymethane (AOM) induced Aberrant Crypt Foci (ACF) in Fisher 344 male rats. Following a one week period of acclimatization Fisher 344 male rats were randomly assigned to groups (n = 6). At seven and eight weeks of age rats received two successive s/c injections of AOM in saline at 16 mg kg-1 body weight. Rats were killed by CO2 asphyxiation at 17 weeks of age. The number of ACF in the proximal and distal colon in the treatment groups ranged from 6.33 (5% Pacific gold) to 15.55 (5% Jetton) and 21.33 (10% Pacific gold) to 52.0 (5% Idagold). Glutathione-S-transferase activity (أƒإ½أ‚آ¼mol mg-1) was significantly (p<0.05) higher in the groups fed canola or mustard seeds compared to the control. Among the treatment groups the highest GST activity (أƒإ½أ‚آ¼mol mg-1) was observed in the rats fed 10% Pacific gold group (32.50). The results from this study show that canola or mustard sprouts and seeds reduced the incidence of AOM-induced ACF and may possibly prevent the incidence of colon cancer., |
